Pathogen Inactivation of Human Serum Facilitates its Clinical Use for Islet Cell Culture and Subsequent Transplantation
نویسندگان
چکیده
منابع مشابه
Mixed lymphocyte islet culture (MLIC) and its use in manipulation of human islet alloimmunogenicity.
Human islets have been transplanted clinically to reverse diabetes, though with poor overall success (reviewed in Hering, Bretzel and Federlin 1988). Inferring from experimental islet transplantation, it is presently suggested that methods for separating the endocrine from the exocrine pancreas portion and/or serological tissue manipulations prior to islet transplantation should be sought in or...
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Gopalakrishnan Loganathan1, Venugopal Subhashree2 and Appakalai N Balamurugan1* 1Clinical Islet Cell Laboratory, Cardiovascular Innovation Institute, Department of Surgery, University of Louisville, Kentucky, USA 2School of Biosciences and Technology, VIT University, Vellore, India *Corresponding author: Appakalai N Balamurugan, Ph. D Clinical Islet Cell Laboratory, Center for Cellular Transpla...
متن کاملSerum and its applicability and use in cell culture
Fetal bovine serum (FBS) has been used in cell culture for decades. In journal articles, it is normally listed in the Materials and Methods section alongside other cell culture ingredients, such as sodium chloride (NaCl) or antibodies. However, unlike the chemically defined NaCl molecule or an antibody that is subjected to questions regarding the identity of the clone and its source, FBS surpri...
متن کاملClinical islet cell transplantation – recent advances
Type-1 diabetes mellitus (T1DM) caused by autoimmune destruction of insulin-producing beta-cells essentially requires treatment with exogenous insulin therapy. Despite the education, technology and improvements in insulin formulations, patients face the ongoing life-threatening hypoglycaemia with poor quality of life as well as progressive disease leading to microand macro-vascular complication...
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ژورنال
عنوان ژورنال: Cell Transplantation
سال: 2011
ISSN: 0963-6897,1555-3892
DOI: 10.3727/096368910x539056